Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 135, Issue 7, Pages 1511-1516Publisher
WILEY
DOI: 10.1002/ijc.28632
Keywords
Biobank; cancer; living tissue bank; xenotransplantation
Categories
Funding
- Guangxi Natural Science Foundation [2013GXNSFAA019253]
- Taihe Hospital Foundation
- VGH & UBC Hospital Foundation
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Biobanks have played a decisive role in all aspects of the field of cancer, including pathogenesis, diagnosis, prognosis and treatment. The significance of cancer biobanks is epitomized through the appropriate application of various -omic techniques (omics). The mutually motivated relationship between biobanks and omics has intensified the development of cancer research. Human cancer tissues that are maintained in intravital biobanks (or living tissue banks) retain native tumor microenvironment, tissue architecture, hormone responsiveness and cell-to-cell signalling properties. Intravital biobanks replicate the structural complexity and heterogeneity of human cancers, making them an ideal platform for preclinical studies. The application of omics with intravital biobanks renders them more active, which makes it possible for the cancer-related evaluations to be dynamically monitored on a real-time basis. Integrating intravital biobank and modern omics will provide a useful tool for the discovery and development of new drugs or novel therapeutic strategies. More importantly, intravital biobanks may play an essential role in the creation of meaningful patient-tailored therapies as for personalized medicine.
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