Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 134, Issue 9, Pages 2118-2125Publisher
WILEY
DOI: 10.1002/ijc.28560
Keywords
Helicobacter pylori; protein; serology; gastric cancer; precancerous gastric lesions
Categories
Funding
- Key International S&T Cooperation Project [2010DFB30310]
- National Basic Research Program of China (973 Program) [2010CB529303]
- National Natural Science Foundation of China [81171989]
- BMWi (ZentralesInnovationsprogrammMittelstand) [KF2016101SK0]
- International Office BMBF [CHN 11/021]
- DZIF German Centre for Infection Research, Munchen, Germany
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Helicobacter pylori-specific proteins are involved in gastric carcinogenesis. To investigate the seroprevalence of six H. pylori-specific antibodies in patients with different gastric histology, and the impact of seropositivities on the evolution of precancerous gastric lesions, a follow-up study was conducted in Linqu County, China. The seropositivities for CagA, VacA, GroEL, UreA, HcpC and gGT were assessed by recomLine analysis in 573 H. pylori-positive subjects and correlated with evolution of precancerous gastric lesions. We found that the score of H. pylori recomLine test was significantly increased in subjects with chronic atrophic gastritis (CAG, p < 0.0001) or intestinal metaplasia (IM, p = 0.0125), and CagA was an independent predictor of advanced gastric lesions, adjusted odds ratios (ORs) were 2.54 (95% CI = 1.42-4.55) for IM and 2.38 (95% CI = 1.05-5.37) for dysplasia (DYS). Moreover, seropositivities for CagA and GroEL were identified as independent predictors for progression of gastric lesions in a longitudinal study, and ORs were 2.89 (95% CI = 1.27-6.59) and 2.20 (95% CI = 1.33-3.64), respectively. Furthermore, the risk of progression was more pronounced in subjects with more than three positive antigens (p(for trend) = 0.0003). This population-based study revealed that seropositivities for CagA and GroEL might be potential markers to identify patients infected with high-risk H. pylori strains, which are related to the development of GC in a Chinese high-risk population, and recomLine test might serve as a tool for risk stratification.
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