Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 132, Issue 7, Pages 1660-1666Publisher
WILEY
DOI: 10.1002/ijc.27777
Keywords
gallbladder cancer; risk factors; gallstones
Categories
Funding
- Indian Council of Medical Research
- Department of Biotechnology, Government of India
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Risk factors for gallbladder cancer (GBC) except gallstones are not well known. The objective was to study the risk factors for GBC. In a casecontrol study, 200 patients with GBC, 200 healthy controls and 200 gallstones patients as diseased controls were included prospectively. The risk factors studied were related to socioeconomic profile, life style, reproduction, diet and bile acids. On comparing GBC patients (mean age 51.7 years; 130 females) with healthy controls, risk factors were chemical exposure [odd ratios (OR): 7.0 (2.718.2); p < 0.001)], family history of gallstones [OR: 5.3 (1.518.9); p < 0.01)], tobacco [OR: 4.1 (1.89.7); p < 0.001)], fried foods [OR: 3.1 (1.75.6); p < 0.001], joint family [OR: 3.2 (1.76.2); p < 0.001], long interval between meals [OR: 1.4 (1.21.6); p < 0.001] and residence in Gangetic belt [OR: 3.3 (1.86.2); p < 0.001]. On comparing GBC cases with gallstone controls, risk factors were female gender [OR: 2.4 (1.34.3); p = 0.004], residence in Gangetic belt [OR: 2.3 (1.24.4); p = 0.012], fried foods [OR: 2.5 (1.44.4); p < 0.001], diabetes [OR: 2.7 (1.26.4); p = 0.02)], tobacco [OR 3.8 (1.78.1); p < 0.001)] and joint family [OR: 2.1 (1.23.4); p = 0.004]. The ratio of secondary to primary bile acids was significantly higher in GBC cases than gallstone controls (20.8 vs. 0.44). Fried foods, tobacco, chemical exposure, family history of gallstones, residence in Gangetic belt and secondary bile acids were significant risk factors for GBC.
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