Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 132, Issue 9, Pages 1971-1976Publisher
WILEY-BLACKWELL
DOI: 10.1002/ijc.27755
Keywords
tumor immunology; targeted therapy; immune-modulation; side-effects
Categories
Funding
- Dutch Cancer Society [UL 2004-3016]
- European Commission
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In recent years, it has become apparent that immunoregulatory processes influence cancer development. The key players in tumor progression are mainly present in the microenvironment of the tumor and the draining lymph nodes. Interventions aimed at shifting tumor-promoting actions toward effective tumor-eradicating immunity are thus foremost required locally. As immune-modulating therapy has been shown to cause many adverse side effects when administered systemically, we strongly advocate the further development of local treatment for cancer immunotherapy.
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