Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 129, Issue 7, Pages 1718-1729Publisher
WILEY
DOI: 10.1002/ijc.25802
Keywords
n-3 polyunsaturated fatty acids; n-6 polyunsaturated fatty acids; colorectal cancer; prospective study; Japanese
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Funding
- Ministry of Health, Labor, and Welfare of Japan
- Japan Society for the Promotion of Science [19689014]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19 shi-2, H21-Sanjigan-Ippan-003]
- Government to the National Cancer Center
- Grants-in-Aid for Scientific Research [19689014] Funding Source: KAKEN
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To date, epidemiologic studies investigating intake of n-3 and n-6 polyunsaturated fatty acids and risk of colorectal cancer are limited, and results remain inconsistent. This is the first prospective study to show the association by subsite (proximal colon, distal colon, rectum). To clarify the role of n-3 and n-6 polyunsaturated fatty acids intake in colon carcinogenesis, we conducted a large, population-based prospective study, characterized by high fish consumption and a wide range of n-3 polyunsaturated fatty acids intakes. Subjects were followed from response to a lifestyle questionnaire in 1995-1999 through 2006. During 827,833 person-years of follow-up (average 9.3 years), we identified 1,268 new colorectal cancer cases (521 colon and 253 rectal for men; 350 colon and 144 rectal for women). Compared to the lowest quintile, the relative risk and 95% confidence interval of developing cancer among the fifth quintile of marine n-3 polyunsaturated fatty acids intake were
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