Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 128, Issue 10, Pages 2274-2283Publisher
WILEY-BLACKWELL
DOI: 10.1002/ijc.25575
Keywords
miR-125b; ovarian cancer; proliferation; BCL3
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Funding
- NNSF of China [30571836]
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Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal formation. This inhibitory effect on OC cell growth was mediated by miR-125b inhibition of the translation of an mRNA encoding a proto-oncogene, BCL3. Furthermore, expression of miR-125b suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-125b may contribute to OC development.
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