Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 128, Issue 3, Pages 635-643Publisher
WILEY
DOI: 10.1002/ijc.25362
Keywords
diabetes; cancer; risk; hyperinsulinemia; hormones; body mass index
Categories
Funding
- National Cancer Institute, NIH, DHHS
Ask authors/readers for more resources
Prior studies of cancer risk among diabetic men have reported inconsistent findings. The aim of this study was to assess the risk of cancer among a large cohort (n = 4,501,578) of black and white U. S. veterans admitted to Veterans Affairs hospitals. The cancer risk among men with diabetes (n = 594,815) was compared to the risk among men without diabetes (n = 3,906,763). Poisson regression was used to estimate adjusted relative risks (RRs) and 95% confidence intervals (CIs). Overall, men with diabetes had a significantly lower risk of cancer (RR = 0.93, 95% CI = 0.93-0.94). Men with diabetes, however, had increased risks of cancers of the liver (RR = 1.95, 95% CI = 1.82-2.09), pancreas (RR = 1.50, 95% CI = 1.42-1.59), biliary tract (RR = 1.41, 95% CI = 1.22-1.62), colon (RR = 1.20, 95% CI = 1.16-1.25), rectum (RR = 1.12, 95% CI = 1.07-1.18), and kidney (RR = 1.09, 95% CI = 1.03-1.16), as well as leukemia (RR = 1.14, 95% CI = 1.08-1.21) and melanoma (RR = 1.13, 95% CI = 1.03-1.24). In contrast, men with diabetes had decreased risks of cancers of the prostate (RR = 0.89, 95% CI 5 0.87-0.91), brain (RR = 0.91, 95% CI = 0.82-0.99), buccal cavity (RR = 0.85, 95% CI = 0.82-0.89), lung (RR = 0.79, 95% CI = 5 0.77-0.80), esophagus (RR = 0.77, 95% CI = 0.72-0.82), and larynx (RR = 0.76, 95% CI = 0.71-0.80). These findings indicate that black and white men with diabetes are at significantly lower risk of total cancer and of two of the most common cancers among U. S. males; lung and prostate cancers. These decreased risks were offset, however, by increased risks of cancer at several sites. Hyperinsulinemia may explain the increased risks of the digestive cancers, while lower testosterone levels, in the case of prostate cancer, and higher BMI, in the case of lung cancer, may explain the decreased risks of those tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available