Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 129, Issue 3, Pages 574-585Publisher
WILEY
DOI: 10.1002/ijc.25709
Keywords
glioblastoma multiforme; cancer-initiating cells; migration; subventricular zones; adult neurogenesis
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Funding
- Fonds National de la Recherche Scientifique de Belgique
- Televie
- Fonds Leon Fredericq
- centre anticancereux pres l'universite de Liege
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In patients with glioblastoma multiforme, recurrence is the rule despite continuous advances in surgery, radiotherapy and chemotherapy. Within these malignant gliomas, glioblastoma stem cells or initiating cells have been recently described, and they were shown to be specifically involved in experimental tumorigenesis. In this study, we show that some human glioblastoma cells injected into the striatum of immunodeficient nude mice exhibit a tropism for the subventricular zones. There and similarily to neurogenic stem cells, these subventricular glioblastoma cells were then able to migrate toward the olfactory bulbs. Finally, the glioblastoma cells isolated from the adult mouse subventricular zones and olfactory bulbs display high tumorigenicity when secondary injected in a new mouse brain. Together, these data suggest that neurogenic zones could be a reservoir for particular cancer-initiating cells.
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