Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 128, Issue 3, Pages 562-573Publisher
WILEY
DOI: 10.1002/ijc.25366
Keywords
PRMT1; PRMT6; Type I protein arginine methyltransferase; epigenetics; ADMA
Categories
Funding
- NIHR
- Cambridge Biomedical Research Centre
- MRC [G0900871] Funding Source: UKRI
- Cancer Research UK [19275] Funding Source: researchfish
- Medical Research Council [G0900871] Funding Source: researchfish
- Grants-in-Aid for Scientific Research [22134008, 22659246] Funding Source: KAKEN
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Protein arginine methylation is a novel post-translational modification regulating a diversity of cellular processes, including histone functions, but the roles of protein arginine methyltransferases (PRMTs) in human cancer are not well investigated. To address this issue, we first examined expression levels of genes belonging to the PRMT family and found significantly higher expression of PRMT1 and PRMT6, both of which are Type I PRMTs, in cancer cells of various tissues than in non-neoplastic cells. Abrogation of the expression of these genes with specific siRNAs significantly suppressed growth of bladder and lung cancer cells. Expression profile analysis using the cells transfected with the siRNAs indicated that PRMT1 and PRMT6 interplay in multiple pathways, supporting regulatory roles in the cell cycle, RNA processing and also DNA replication that are fundamentally important for cancer cell proliferation. Furthermore, we demonstrated that serum asymmetric dimethylarginine (ADMA) levels of a number of cancer cases are significantly higher than those of nontumor control cases. In summary, our results suggest that dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis and that these Type I arginine methyltransferases are good therapeutic targets for various types of cancer.
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