Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 124, Issue 9, Pages 2082-2087Publisher
WILEY-LISS
DOI: 10.1002/ijc.24144
Keywords
trichomonosis; Trichomonas vaginalis; sexually; transmitted infection; prostate cancer; epidemiology
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Funding
- NCI NIH HHS [P01 CA108964-04, P01 CA108964, P30 CA023100] Funding Source: Medline
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We previously observed a positive association between a history of trichomonosis, a sexually transmitted infection caused by the protozoan, Trichomonas vaginalis, and prostate cancer risk in the Health Professionals Follow-up Study. To determine the reproducibility of this finding, we conducted a second, prospective investigation of trichomonosis and prostate cancer in the Prostate Cancer Prevention Trial. Participants were men (>= 55 years of age) with no evidence of prostate cancer. at enrollment (n = 18,8821). Men were screened annually for prostate cancer, and if not diagnosed during the trial, were offered an end-of-study prostate biopsy. Cases were a sample of men diagnosed with prostate cancer on any biopsy after visit 2 or on their end-of-study biopsy (it = 616). Controls were men not diagnosed with prostate cancer during the trial or on their end-of-study biopsy (n = 616). Controls were frequency-matched to cases by age, treatment arm, and family history of prostate cancer. Serum from visit 2 was tested for anti-T. vaginalis IgG antibodies. No association was observed between T. vaginalis serostatus and prostate cancer. 21.5% of cases and 24.8% of controls had low seropositivity, and 15.2% and 15.0% had high seropositivity. Compared to seronegative men, the odds ratio of prostate cancer for men with low seropositivity was 0.83 95% confidence interval (Cl): 0.6.3-1.09), and that for men with high seropositivity was 0.97 (95% Cl: 0.70-1.34). Given the original strong biologic rationale and potential for prevention, additional studies are warranted to help resolve discrepancies between study findings and to further investigate this hypothesis from a variety of different approaches. (C) 2008 Wiley-Liss, Inc.
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