Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 125, Issue 8, Pages 1961-1964Publisher
WILEY
DOI: 10.1002/ijc.24519
Keywords
stomach cancer; prostate stem cell antigen; polymorphism; case-control study
Categories
Funding
- Ministry of Education, Science, Sports, Culture and Technology of Japan
- Ministry of Health, Labour and Welfare of Japan
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A recent whole-genome association study identified a strong association between polymorphisins in the prostate stem cell antigen (PSCA) gene and stomach cancer risk. In this case-control study, we aimed to validate this association, and further to explore environmental factors possibly interacting with PSCA polymorphisms in 708 incident stomach cancer cases and 708 age-sex matched controls. The association between PSCA polymorphisms and Helicobacter pylori infection was also examined. We found that rs2294008 and rs2976392, which were strongly linked to each other (D' = 1.00), were significantly associated with stomach cancer risk. Per allele odds ratio for rs2994008 was 1.40 (95% confidence interval: 1.19-1.65; p = 3.7 x 10(-5)). We found significant interaction with a family history of stomach cancer in first-degree relatives (P-heterogeneity = 0.009). Similar to originally reported association, we found significant heterogeneity between diffuse and intestinal type (p-heterogeneity = 0.007). No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation. (C) 2009 UICC
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