Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 124, Issue 12, Pages 2948-2953Publisher
WILEY
DOI: 10.1002/ijc.24307
Keywords
DNA repair; glioma; XRCC3; tagging SNP; haplotype-based association study
Categories
Funding
- China National Key Basic Research Program [2002CB512902]
- National '211' Environmental Genomics
Ask authors/readers for more resources
In mammalian cells, X-ray repair cross-complementing group3 (XRCC3) plays an important role in the DNA double-strand breaks (DSBs) repair by homologous recombination. Genetic polymorphisms in the XRCC3 gene may potentially affect the repair of DSBs and thus confer susceptibility to gliomas. In this study, we used a haplotype-based approach to investigate whether 4 tagging single nucleotide polymorphisms of the XRCC3 gene are associated with risk of gliomas in 771 glioma patients and 752 cancer-free controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by the unconditional logistic regression, and haplotype associations were estimated using Haplo.Stat. After adjustment for age and sex, the variant G allele of rs861530 and T allele of rs3212092 were significantly associated with an increased risk of gliomas (AG/GG versus AA: adjusted OR = 1.44, 95% CI = 1.15-1.80, p = 0.001 and CT/TT versus CC: adjusted OR = 1.66, 95% CI = 1.12-2.46, p = 0.013, respectively). Consistent with these results, XRCC3 haplotype GGCC containing rs861530 G allele and haplotype AGTC containing rs3212092 T allele were also significantly associated with an elevated risk of gliomas compared with the common haplotype AGCC (adjusted OR = 1.35, 95% CI = 1.14-1.58, p = 0.000 and adjusted OR = 1.67, 95% CI = 1.11-2.52, p = 0.015, respectively). Our results suggest that common genetic variants in the XRCC3 gene may modulate glioma risk. (C) 2009 UICC
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available