Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 123, Issue 9, Pages 2048-2056Publisher
WILEY-LISS
DOI: 10.1002/ijc.23763
Keywords
biomarker; epigenetic regulation; hMOF
Categories
Funding
- Strategiefords
- Helmholtz-Gemeinschaft Deutscher Forschungszentren
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In a study on gene deregulation in ovarian carcinoma we found a mRNA ceding for a 350 kDa protein, Drop1, to be downregulated 20- to 180-fold in the majority of ovarian and mammary carcinomas. The mRNA is encoded by a set of exons in the 5' region of the SYNE1 gene. Immunohistochemical staining for Drop1 protein by a specific monoclonal antibody corresponds to the pattern seen for the mRNA. cDNA arrays of matched pairs of tumor and normal tissue and in situ hybridizations confirmed the drastic loss of Drop1 mRNA as a common feature in uterus, cervix, kidney, lung, thyroid and pancreas carcinomas, already at early tumor stages and in all metastases. Two-hybrid studies suggest a role of this deficiency in the malignant progression of epithelial tumors. (c) 2008 Wiley-Liss, Inc.
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