Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 10, Issue 6, Pages 596-601Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.8780
Keywords
Adrenal androgens; Backdoor Pathway; Prostate cancer; Dihydrotestosterone; CYP17A1
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Almost all men who present with advanced prostate cancer (CaP) and many men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to describe the evolution of adrenal androgen blockade, how new androgen measurement methods have furthered understanding of androgen metabolism, and how further understanding of the backdoor pathway of androgen metabolism may lead to interventions that extend survival even more.
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