Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 10, Issue 5, Pages 543-+Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.8888
Keywords
DLG5; epithelial cell polarity; EMT; cell proliferation; migration
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Funding
- National Natural Science Foundation of China [81272342]
- Program for New Century Excellent Talents, Ministry of Education of China [NCET-10-0677]
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Failure in establishment and maintenance of epithelial cell polarity contributes to tumorigenesis. Loss of expression and function of cell polarity proteins is directly related to epithelial cell polarity maintenance. The polarity protein discs large homolog 5 (DLG5) belongs to a family of molecular scaffolding proteins called Membrane Associated Guanylate Kinases (MAGUKs). As the other family members, DLG5 contains the multi-PDZ, SH3 and GUK domains. DLG5 has evolved in the same manner as DLGI and ZOI, two well-studied MAGUKs proteins. Just like DLGI and ZOI, DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton. Since the roles of DLG5 in inflammatory bowel disease (IBD) and Crohn's disease (CD) have been reviewed, here, our review focuses on the roles of DLG5 in epithelial cell polarity maintenance and cancer development.
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