Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 9, Issue 5, Pages 435-443Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.6087
Keywords
c-kit receptor; signal transduction; tumor; targeted therapy
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Funding
- Zhejiang Provincial Natural Science Foundation of China [LY12B02019]
- Public Technology Research and Social Development Project of Zhejiang Province [2011C23004]
- Qianjiang Talents Program of Zhejiang Province [2009R10002]
- Program for Zhejiang Leading Team of Science and Technology Innovation [2011R50021]
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As an important member of tyrosine kinase family, c-kit receptor causes specific expression of certain genes, regulates cell differentiation and proliferation, resists cell apoptosis, and plays a key role in tumor occurrence, development, migration and recurrence through activating the downstream signaling molecules following interaction with stem cell factor (SCF). The abnormality of SCF/c-kit signaling pathway is closely related to some certain tumors. The discovery of c-kit receptor-targeted drugs has promoted clinical-related cancer's diagnosis and treatment. In this paper, we review recent research progress on c-kit receptor-mediated signal transduction and its potential therapeutic application as a target in tumor-related diseases.
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