Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 9, Issue 6, Pages 550-556Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.6257
Keywords
subcutaneous adipose tissue; visceral adipose tissue; RNA-seq; inflammatory; fatty acid metabolism; pig
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Funding
- Specialized Research Fund of Ministry of Agriculture of China [NYCYTX-009]
- Project of Provincial Twelfth Five Years' Animal Breeding of Sichuan Province [2011YZGG15]
- National Special Foundation for Transgenic Species of China [2011ZX08006-003]
- National High Technology Research and Development Program of China (863 Program) [2013AA102502]
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Functional differences in the different types of adipose tissue and the impact of their dysfunction on metabolism are associated with the regional distribution of adipose depots. Here we show a genome-wide comparison between the transcriptomes of one source of subcutaneous and two sources of visceral adipose tissue in the pig using an RNA-seq approach. We obtained similar to 32.3 million unique mapped reads which covered similar to 80.2% of the current annotated transcripts across these three sources of adipose tissue. We identified various genes differentially expressed between subcutaneous and visceral adipose tissue, which are potentially associated with the inflammatory features of visceral adipose tissue. These results are of benefit for understanding the phenotypic, metabolic and functional differences between different types of adipose tissue that are deposited in different body sites.
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