Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 8, Issue 6, Pages 831-837Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.4493
Keywords
pig; subcutaneous adipose tissue; visceral adipose tissue; DNA methylation; MeDIP-seq
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Funding
- National Special Foundation for Transgenic Species of China [2009ZX08009-155B, 2011ZX08006-003]
- Project of Provincial Twelfth 5 Years' Animal Breeding of Sichuan Province [2011-YZGG-15]
- International Science & Technology Cooperation Program of China [2011DFB30340]
- National Natural Science Foundation of China [30901024]
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It is well established that the metabolic risk factors of obesity and its comorbidities are more attributed to adipose tissue distribution rather than total adipose mass. Since emerging evidence suggests that epigenetic regulation plays an important role in the aetiology of obesity, we conducted a genome-wide methylation analysis on eight different adipose depots of three pig breeds living within comparable environments but displaying distinct fat level using methylated DNA immunoprecipitation sequencing. We aimed to investigate the systematic association between anatomical location-specific DNA methylation status of different adipose depots and obesity-related phenotypes. We show here that compared to subcutaneous adipose tissues which primarily modulate metabolic indicators, visceral adipose tissues and intermuscular adipose tissue, which are the metabolic risk factors of obesity, are primarily associated with impaired inflammatory and immune responses. This study presents epigenetic evidence for functionally relevant methylation differences between different adipose depots.
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