Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 7, Issue 7, Pages 1027-1036Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.7.1027
Keywords
Foxp3(+) regulatory T cells; Extranodal NK/T cell lymphoma; tumor infiltrating lymphocytes; EBV
Categories
Funding
- National Natural Science Foundation of China [224 (30872981)]
- Guangdong Province Natural Science Foundation [10151008901000156]
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Foxp(3+) regulatory T lymphocytes (Tregs) usually act as an immune suppressor and correlate with poorer survival in malignancies. This study aims to investigate the distribution and characterization of Foxp(3+) subset in peripheral blood mononuclear cells (PBMCs) and tumor tissues from extranodal NK/T cell lymphoma (ENKTL). Our study showed the percentage of Foxp(3+) subset from PBMC was significantly higher than that of healthy individuals (P<0.001). The Foxp(3+) subset from PBMCs expressed CD45RO, CTLA4, GITR, CCR7, and had an IL-10(high)IFN gamma(+)TGF beta+IL-2(low)IL-17(low) cytokine secreting phenotype. Interestingly, the existence of EBV antigen-specific CD8(+)Foxp3(+) Tregs was discovered in ENKTL. Furthermore, the high density of Foxp3(+) TILs was associated with improved progression-free survival (PFS) in ENKTL patients (P<0.05). Collectively, our study implicates that EBV antigens could induce antigen-specific CD8(+)Foxp3(+) Tregs in ENKTL, and Foxp3(+) TILs is an independent factor for PFS in ENKTL.
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