Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 7, Issue 5, Pages 567-574Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.7.567
Keywords
gastric cancer; cell proliferation; miR-148a; p27
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Funding
- Chinese National Key Program on Basic Research [2011CB504200, 2011CB901601]
- Chinese Key Program for Drug Invention [2009ZX09501-027]
- Chinese Key Project for the Infections Disease [2009ZX10002-016]
- National Natural Science Foundation of China [31030040, 30700423, 30900863]
- Beijing Natural Science Foundation of China [5082018]
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Accumulating evidence has shown that miRNAs are aberrantly expressed in human gastric cancer and crucial to tumorigenesis. Herein, we identified the role of miR-148a in gastric cell proliferation. miR-148a knockdown inhibited cell proliferation in gastric cancer cell lines. Conversely, miR-148a overexpression promoted cell proliferation and cell cycle progression. p27, a key inhibitor of cell cycle, was verified as the target of miR-148a, indicating miR-148a might downregulate p27 expression to promote gastric cell proliferation. Moreover, we confirmed that miR-148a expression was frequently and dramatically downregulated in human advanced gastric cancer tissues, and observed a good inverse correlation between miR-148a and p27 expression in tumor samples. Thus, our results demonstrated that miR-148a downregulation might exert some sort of antagonistic function in cell proliferation, rather than promote cell proliferation in gastric cancer.
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