Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
Volume 6, Issue 1, Pages 51-67Publisher
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.6.51
Keywords
PML-NB; SUMOylation; Cytoscape; protein-protein interaction; network
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Funding
- University of Antwerp [BOF-UA-2005]
- Institute for the Promotion of Innovation through Science and Technology in Flanders (IWT-Vlaanderen)
- Flemish Institute supporting Scientific-Technological Research in industry (IWT) [IWT-600450]
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Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling 'the PML-ome', we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot.
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