Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 120, Issue -, Pages 853-858Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2018.08.154
Keywords
Se-containing tea polysaccharide; Regular tea polysaccharide; Se-yeast; Antitumor activity; Sarcoma 180
Funding
- Natural Science Foundation of Shanghai [16 ZR1425200]
- National Key Research and Invention Program of the Thirteenth [2017YFD0400800]
- Shanghai Agricultural Achievement Transformation Fund [143919N0500, 143919N0502]
- Shanghai Wangwang Food Group Co., Ltd. commissioned the program [2017MH196, C-6105-15-007]
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Selenium (Se)-containing polysaccharide, a Se-conjugate macromolecule, generally exhibited higher antitumor activity than its regular polysaccharide. Previously, we extracted Se-containing tea polysaccharides (Se-TPS) from Se-enriched tea, and explored its structure and antioxidant activity. In this study, we investigated antitumor activity of Se-TPS on sarcoma 180 (S-180), and compared with its regular polysaccharides TPS and dietary supplement Se-yeast. In vitro antitumor activity of Se-TPS was evaluated by MTT and LDH assays, and the results indicated that Se-TPS can significantly inhibit the proliferation of S-180 in dose-dependent manner (R-2 = 0.97, p < 0.0001). In S-180 cancer xenograft model in Kunming mice, Se-TPS oral administration at three doses of 50, 100 and 200 mg/kg body weight daily for 13 days resulted in significant tumor regression. At the same dose, Se-TPS exhibited significantly higher antitumor activity than TPS and Se-yeast. Importantly, Se-TPS can significantly increase the spleen and thymus indices of tumor-bearing mice, suggesting the safety and immunomodulatory activity of Se-TPS. Therefore, Se-TPS may be a desirable antitumor agent for therapeutic and immunomodulatory applications. (C) 2018 Published by Elsevier B.V.
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