Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 67, Issue -, Pages 336-342Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.03.031
Keywords
Neuroprotective activity; Antioxidant activity; Sargassum
Funding
- Ocean Public Welfare Scientific Research Project [201005024-201405040]
- CAS-Guangdong Provincial Joint Project [20128090400028]
- Doctorial Fund of Shandong Province [BS2011YY066]
- Science and Technology Project of Shandong Province [2011GHY11529]
- Science and Technology program of applied basic research projects of Qingdao Municipal [12-1-4-8-(3)-jch]
- Prospective Joint Research Projects of Jiangsu Province [BY2011189]
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Heteropolysaccharides were extracted from Sargassum integerrimum (S.I), Sargassum maclurei (S.M), Sargassum naozhouense (S.N), Spiraea thunbergii (S.T), Sargassum hemiphyllum (S.H) and Sargassum fusiforme (S.F), and their neuroprotective effects and antioxidant activities were investigated. It showed that S.I, S.N, S.T and S.F exhibited neuroprotective activities, whereas S.H and S.M did not. For this reason, they were separated by anion-exchange chromatography. It was apparent that the fraction 2 represented the principal difference between the active and non-active compounds. However, it did not correlate with neuroprotective effect. In addition, the results on antioxidant activities showed that the hydroxyl-radical scavenging effect contribute to the neuroprotective effect of S.T and S.N, and the DPPH-radical scavenging effect and reducing power contribute to S.T, S.F and S.I. However, the superoxide-radical scavenging effect did not correlate with neuroprotective activity. The conclusion was that the neuroprotective activity of the family of compounds investigated depended on a variety of factors. (C) 2014 Elsevier B.V. All rights reserved.
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