Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 61, Issue -, Pages 58-62Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.05.023
Keywords
Chitosan; 1,2,3-Triazole; Click reaction; Characterization; Antifungal activity
Funding
- National High Technology Research and Development Program (863 Program) of China [2011AA09070405]
- Innovational Foundation of Chinese Academy of Sciences [KZCX2-EW-Q214]
- commonweal item of State Oceanic Administration People's Republic Of China [200905021-2]
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With an aim to discover novel chitosan derivatives with significant activities against crop-threatening fungi, (1,2,3-triazol-4-yl)methyl nicotinate chitosan (TAMNCS) was prepared via azide-alkyne click reaction. Its structure was characterized by FT-IR, H-1 NMR, elemental analysis, DSC, and SEM. In vitro antifungal properties of TAMNCS against Rhizoctonia solani Kuhn (R. solani), Stemphylium solani weber (S. solani), and Alternaria porri (A. porri) were studied at the concentrations ranged from 0.25 mg/mL to 1.0 mg/mL. Experiments conducted displayed the derivative had obviously enhanced antifungal activity after chemical modification compared with original chitosan. Moreover, it was shown that TAMNCS can 94.2% inhibit growth of A. pouf at 1.0 mg/mL, while dose at which the fungicide triadimefon had lower inhibitory index (62.2%). The primary antifungal results described here indicate this derivative may be a promising candidate as an antifungal agent. (C). 2013 Elsevier B.V. All rights reserved.
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