Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 58, Issue -, Pages 225-230Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.04.005
Keywords
Enteromorpha linza; Sulfation; Antioxidant activity; Anticoagulant activities
Funding
- Project of Zhejiang Key Laboratory of Exploitation and Preservation of Coastal Bio-resource [J2012008]
- National Natural Science Foundation of Shandong [ZR2012DL13]
- National Natural Science Foundation of China [41206129]
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Sulfated polysaccharides exerted potent biological property which was relative to degree of sulfation, molecular weight, substitution position and chain conformation. In present study, the polysaccharide with low molecular weight (LEP) from Enteromorpha linza was sulfated with chlorosulfuric acid in formamide. The obtained polysaccharide sulfate was selected to evaluate their antioxidant activities and the anticoagulant activity in the coagulation assays, activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT). The data obtained in vitro models indicated that high DS and moderate Mw showed the best anticoagulant and antioxidant activities. (C) 2013 Elsevier B.V. All rights reserved.
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