Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 58, Issue -, Pages 47-56Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2013.03.054
Keywords
Sericin; ROS-scavenging activity; Anti-tyrosinase activity; Anti-elastase activity; Anti-proliferative activity; Anti-IFN gamma activity
Funding
- [EI5227 FIBRO-SPHERE]
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Some biological properties of Bombyx mori sericins from twenty strains were investigated, fourteen fed with artificial diet, two with fresh mulberry leaves and four with both diets. Sericin exhibited ROS-scavenging, anti-tyrosinase and anti-elastase properties, the strain significantly influenced these properties, while diet only influenced the anti-tyrosinase activity. Sericins were clustered into 5 groups and one sericin from each group was further studied: sericins showed anti-proliferative activity on in vitro stimulated peripheral blood mononuclear cells; some strains decreased in vitro secretion of IFN gamma, while no effects were observed on TNF alpha and IL10 release. Therefore, a mixture of sericins extracted from the most promising strains may be useful for dermatological and cosmetic use. (C) 2013 Elsevier B.V. All rights reserved.
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