Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 58, Issue -, Pages 220-224Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.03.060
Keywords
Poly (lactic acid); Chitosan; Collagen; Nanofibers; BOEC; eNOS; Wound healing
Funding
- Indian Council for Medical Research (ICMR), Government of India (ICMR-UMN Joint Initiative) [5/3/8/3/UOM/2011-RHN]
- University of Minnesota (UMN) (ICMR-UMN Joint Initiative) [5/3/8/3/UOM/2011-RHN]
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In this work, the attachment, viability and functionality of rat Blood Outgrowth Endothelial Cells (rBOEC) and genetically modified rBOEC (rBOEC/eNOS-GFP), which over express endothelial nitric oxide synthase (eNOS), were investigated on Poly(lactic acid) (PLA)-chitosan and PLA-chitosan-collagen nanofibrous scaffolds. Both the cell types displayed good attachment, remained viable and functional on both scaffolds. Moreover, incorporation of collagen in the scaffold helped in sustaining the rBOEC for upto one week, although collagen was not found necessary for rBOEC/eNOS-GFP. We conclude that PLA-chitosan based nanofibrous scaffolds can be a potential candidate for BOEC based wound healing applications. (C) 2013 Elsevier B.V. All rights reserved.
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