Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 61, Issue -, Pages 43-49Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.06.006
Keywords
MicroRNA; miR-483; Osteoarthritis; Cartilage; IGF2
Funding
- Natural Science Foundation of China [81101373]
- Natural Science Foundation Heilongjiang Province for outstanding youth [JC201110]
- Education Department of Heilongjiang Province for the Returned Overseas Scholars [1152hz24]
- Heilongjiang Postdoctoral Fund [LBH-Z12172]
- Science and Technology Planning Project of Heilongjiang Province [LC06C21]
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MicroRNAs (miRNAs) have been shown to be important regulators in the pathogenesis of osteoarthritis (OA). The objective of this study was to determine the expression levels of miR-483, miR-483*, their host gene (Igf2) and other cytokines in a murine model of OA. The expression of miR-483 was significantly up-regulated in old mouse and in all of the operation groups, particularly the group assessed 1 week after surgery. The expression of miR-483* was significantly increased in the old mouse group and the group assessed 5 weeks after surgery. The expression of miR-483 was negatively correlated with the expression of (mRNA) Bmp7 and TgfB and positively correlated with Mmp13 by Pearson correlation analysis, while miR-483* was positively correlated with Il1B. Surprisingly, there was no correlation between the expression of either miR-483 or miR-483* and Igf2. This study shows that the expression of miR-483 and miR-483* is up-regulated in murine OA. These data suggest that miR-483 and miR-483* may play critical roles in early and later pathogenesis of OA, respectively, without the involvement of their host gene Igf2. (C) 2013 Elsevier B.V. All rights reserved.
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