Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 62, Issue -, Pages 352-357Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.09.043
Keywords
Anti-cancer; Dextran; NMR; Pediococcus pentosaceus; SEM
Funding
- Department of Biotechnology, Ministry of Science and Technology, India
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The porous branched dextran of molecular mass 2.93 x 10(5) Da with 50% overall yield (4.5 mg/ml) was produced from Pediococcus pentosaceus CRAG3 (GenBank ID: JX679020), a novel isolate from fermented cucumber. It contained glucose monomers linked through 75% alpha-(1,6) linkage with 25% (alpha-1,3) branching as displayed by spectroscopic analysis. The peak analysis showed alpha-(1,3) branching after every five glucose units of main chain. In vitro cytotoxicity analysis of dextran displayed anti-cancer activity against cervical cancer (HeLa) and colon cancer (HT29) cell lines opening new horizons in its pharmaceutical applications. Dextran showed enhanced growth of macrophage lines revealing its biocompatible nature. (C) 2013 Elsevier B.V. All rights reserved.
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