Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 54, Issue -, Pages 270-275Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2012.12.037
Keywords
Lactic acid bacteria; Lactobacillus plantarum; Antioxidant activity; Exopolysaccharide
Funding
- Natural Science Foundation for the Youth [31201394]
- Natural Science Foundation of China [31071574]
- Earmarked Fund for Modern Agro-industrial Technology Research Systems in China [CARS-37]
- National Public Benefit Research (Agriculture) Foundation [200903043]
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A neutral exopolysaccharide (EPS), designated LPC-1, was isolated from the culture of Lactobacillus plantarum C88 and purified by ion-exchange and gel-permeation chromatography. LPC-1 had an average molecular weight of 1.15 x 10(6) Da, and it was composed of galactose and glucose with a molar ratio of 1:2. The antioxidant activity of LPC-1 was evaluated with the in vitro scavenging abilities on hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. The results indicated that LPC-1 had good scavenging ability on hydroxyl radicals. Furthermore, the protective effect of LPC-1 on H2O2-induced Caco-2 cells oxidative injury was investigated. As results, LPC-1 inhibited the formation of malondialdehyde (MDA) and raised the activities of superoxide dismutase (SOD) and total antioxidant capacities (T-AOC) in a dose-dependent manner. These results demonstrate that the EPS from L plantarum C88 has antioxidant effects that may involve scavenging of reactive oxygen species (ROS), up-regulation of enzymatic and non-enzymatic antioxidant activities, and reduction of lipid peroxidation. (C) 2012 Elsevier BM. All rights reserved.
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