Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 59, Issue -, Pages 192-200Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.04.054
Keywords
Pectic polysaccharides; Rosa damascena Mill.; Waste rose petals; Intestinal immune system modulating activity; Arabino-3,6-galactan
Funding
- Quality Assurance Framework of Higher Education from Ministry of Education, Culture, Sports, Science and Technology in Japan
- Kitasato University
- Matsumae International Foundation, Tokyo, Japan
- Grants-in-Aid for Scientific Research [23590895] Funding Source: KAKEN
Ask authors/readers for more resources
A water-soluble polysaccharide (RP-1) was obtained from distilled rose petals of Rosa damascena Mill. as an attempt for valorization of the waste. RP-1 showed in vitro intestinal immune system modulating activity through Peyer's patch cells and IL-6 producing activity from macrophages. RP-1 lost most of its immunomodulating activity by degradation of the carbohydrate moiety with periodate. RP-1 was fractionated by anion-exchange and gel filtration chromatography and some of the fractions showed significant intestinal immune system modulating activity. The active fractions were suggested to be pectic polysaccharides and type II arabino-3,6-galactan from the component sugar analyses and the reactivity with Yariv antigen. When some active fractions were digested with endo alpha-D-(1 -> 4)-polygalacturonase, highest molecular weight fragments which were considered as rhamnogalacturonan I, showed potent immunomodulating activities. To our knowledge, this is a first report which explores the possibility for utilization of waste rose petals as a source of immunomodulating pectic polysaccharides. (C) 2013 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available