Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 60, Issue -, Pages 262-267Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2013.06.012
Keywords
Fish gelatin; Scaffold; Bio-degradation; Mechanical properties; Microstructure
Funding
- Department of Biotechnology, Govt. of India, New Delhi, India
- Dean, Fisheries College and Research Institute, Tamil Nadu Fisheries University, Tuticorin, India
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Four types of fish gelatin scaffolds viz. gelatin (G), gelatin-chitosan (GC), gelatin-calcium acetate (GCA) and gelatin-chitosan-calcium acetate (GCCA) prepared were investigated for their functional properties, biomechanical strength, microstructural changes in relation to biodegradation. GC scaffold was superior with pH 3.15 and viscosity 9.40 cP. Chitosan and calcium acetate improved tensile strength (TS) and Young's modulus (YM), but lowered elongation at break (EAB). GCCA scaffold possessed moderate TS of 19.6 MPa, EAB of 4.76% and YM of 185 MPa. Foaming ability ratio of GC scaffold was high (3.41). GCA and GCCA scaffolds remained for 4 days before complete in vitro biodegradation. GC scaffold had larger cavities (180-300 mu m) that were responsible for low swelling ratios and shrinkage factor. GCCA scaffold with moderate swelling rates, mechanical, functional properties and lowered biodegradation rate were found more suitable for biomedical applications. (C) 2013 Elsevier B.V. All rights reserved.
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