Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 51, Issue 4, Pages 343-350Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2012.05.023
Keywords
PHBV; Chitosan; Electrospinning; Scaffold; Skin healing
Funding
- Fundacao para a Ciencia e Tecnologia (FCT, Lisbon, Portugal) [SFRH/BD/38881/2007]
- QOPNA research unit [PEst-C/QUI/UI0062/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/38881/2007] Funding Source: FCT
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The purpose of this study was to evaluate hybrid poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/chitosan nanofibrous mats as scaffolds for skin engineering. In vitro studies were carried out to test the potential of the scaffolds for fibroblasts adhesion, viability, and proliferation (L929 cell line). The in vivo performance was also studied in a full-thickness wound healing model. PHBV/chitosan 4:1 (w/w) exhibited a higher in vitro biocompatibility and a better ability for cell adhesion and growth, compared to PHBV/chitosan 2:3 (w/w). The in vivo assay also revealed the better performance of this scaffold, improving the wound healing process in rats. (C) 2012 Elsevier B.V. All rights reserved.
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