Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 50, Issue 1, Pages 294-299Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2011.11.013
Keywords
Chitosan; Nano-hydroxyapatite; Copper-zinc alloy; Cytotoxicity; Antibacterial activity; Bone
Funding
- SRM University
- Indian Council for Medical Research, India [5/13/2009-NCD-III, 80/10/2010-BMS]
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The current study involves fabrication and characterization of bio-composite scaffolds containing chitosan (CS), nano-hydroxyapatite (nHAp) and Cu-Zn alloy nanoparticles (nCu-Zn) by freeze drying technique. The fabricated composite scaffolds (CS/nHAp and CS/nHAp/nCu-Zn) were characterized by SEM, EDX, XRD and FT-IR studies. The addition of nCu-Zn in the CS/nHAp scaffolds significantly increased swelling, decreased degradation, increased protein adsorption, and increased antibacterial activity. The CS/nHAp/nCu-Zn scaffolds had no toxicity towards rat osteoprogenitor cells. So the developed CS/nHAp/nCu-Zn scaffolds have advantageous and potential applications over the CS-nHAp scaffolds for bone tissue engineering. (C) 2011 Elsevier B.V. All rights reserved.
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