Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 51, Issue 1-2, Pages 45-55Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.04.018
Keywords
Gastro-retentive drug delivery; Sodium alginate; Sodium carboxymethyl cellulose; MAS; Composite beads; Amoxicillin
Funding
- University Grants Commission (UGC), New Delhi, India [KU/SCH/UGC/RFSMS/2008-09]
- All India Council for Technical Education [1-51/RIFD/EF/2011-12]
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Composite blend microbeads of sodium alginate (NaAlg) with sodium carboxymethyl cellulose (NaCMC) containing magnesium aluminum silicate (MAS) particles and enteric coated with chitosan have been prepared to achieve controlled release (CR) of amoxicillin in stomach environment. The composite beads have been characterized by X-ray diffraction (XRD) to study drug distribution, DSC for understanding thermal stability and Fourier transform infrared (FTIR) spectroscopy to investigate chemical interactions as well as to assess the structure of the drug-loaded formulations. Surface morphology of the beads was investigated by scanning electron microscopy (SEM). The size distribution of beads loaded with drug as studied by particle size analyzer was in the range of 745-889 mu m. The beads exhibited quite widely varying encapsulation efficiencies from 52 to 92%. Equilibrium swelling of the beads measured in water and in vitro release of amoxicillin in pH 1.2 medium suggests that drug release depends on polymer blend composition, concentration of MAS and extent of enteric coating. (c) 2012 Elsevier B.V. All rights reserved.
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