Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 50, Issue 4, Pages 1144-1150Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2012.02.002
Keywords
Microcapsules; Immunity; Essential oil; Acute otitis media; Oxidative injury
Funding
- Science Research grants for the 10th and 11th 5-year plan [2004BA720A19-01]
- National Natural Science Foundation of China [30973167]
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The processing parameters of pump speed, inlet air temperature, outlet air temperature and homogenization pressure were evaluated. Encapsulation efficiency is high with a satisfied releasing rate. Then, acute otitis media (AOM) animal model was built and diet containing orange peel essential oil microcapsules were administrated to AOM animals. Pharmacological test showed that orange peel essential oil treatment could decrease serum and cochlea malondialdehyde (MDA), immunoglobulins A (IgA), immunoglobulins G (IgG), immunoglobulins M (IgM) levels and increase antioxidant enzymes activities. It can be concluded that orange peel essential oil treatment could decrease oxidative injury in acute otitis media rats. (C) 2012 Elsevier B.V. All rights reserved.
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