Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 50, Issue 1, Pages 125-130Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2011.10.008
Keywords
EPI liposome; Newcastle disease vaccine; Immune response; Immune protection
Funding
- National Natural Science Foundation of China [30901085, 30871887]
- National Science & Technology Pillar Program of China [2011BAD341302]
- National Special Fund for Agro-scientific Research in the Public Interest of China [201003075]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Three preparations of epimedium polysaccharide-propolis flavone immunopotentiator (EPI), EPI liposome, EPI suspension and EPI watery solution were prepared. In immune response test, their adjuvanticities were compared in 14-day-old chickens vaccinated with Newcastle disease (ND) vaccine. In immune protection test, the effects of the three preparations on Newcastle disease virus (NDV) infection were compared in chickens vaccinated with ND vaccine then challenged with NDV. The results displayed that EPI liposome could enhance the antibody titer, T lymphocyte proliferation and the concentrations of interferon-gamma and interleukin-6, when compared with the other two preparations. In EPI liposome group, the antibody titers, lymphocyte proliferation and protective rate were the highest, while the mortality and morbidity were the lowest, in comparison with the other groups. These results indicated that liposome could enhance the immune effect of EPI on ND vaccine and would be expected as the suitable dosage form of this immunopotentiator. (C) 2011 Elsevier B.V. All rights reserved.
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