Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 50, Issue 3, Pages 747-753Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2011.12.003
Keywords
Alginate; Biomineralization; Hydrophobically modified; Multi-responsive; Smart drug delivery
Funding
- National Natural Science Foundation of China [20874090]
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Hydrophobically modified biomineralized polysaccharide alginate membrane with smart drug release property using sodium palmitate as the hydrophobic component was prepared via a one-step method. The formation of CaHPO4 in the membrane was clearly identified through scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy. Indomethacin release profiles of the modified alginate membrane were found to be pH- and thermo-responsive. The drug release of modified alginate membrane was around 60% within 12 h, while that of the alginate membrane was higher than 90%. These results indicate that the hydrophobic and biomineralized polysaccharide components can hinder the permeation of the encapsulated drug and reduce the drug release effectively. The resulting membrane can be used as smart materials for sustained dual-responsive drug delivery. (C) 2011 Elsevier B.V. All rights reserved.
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