Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 46, Issue 1, Pages 115-122Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2009.11.005
Keywords
Angelica sinensis; Polysaccharide; Anti-tumor
Funding
- National Natural Science Foundation of China [30701081]
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In this study, three acidic polysaccharides (APS-3a, APS-3b and APS-3c) were obtained from Angelica sinensis (Oliv.) Diels. They displayed different structural features and anti-tumor activities. APS-3b and APS-3c significantly inhibited the growth of 5780 tumors and increased the life spans of 5780 tumor-bearing mice, whereas APS-3a had no significant effect. Further experiments showed that APS-3b and APS-3c could cause a concentration-dependent proliferation of the splenocytes, up-regulate IFN-gamma, IL-2 and IL-6 mRNA expressions in splenocytes and stimulate the productions of NO and TNF-alpha in peritoneal macrophages. Taken together, the three acidic polysaccharides displayed different anti-tumor activities which were associated with their different structural characteristics. (C) 2009 Elsevier B.V. All rights reserved.
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