Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 47, Issue 3, Pages 420-424Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2010.05.021
Keywords
Sarcodon aspratus (Berk.) S. Ito.; Edible mushroom; Polysaccharide; Glucan; Immunological activity
Funding
- Analytical and Testing Center
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A water-soluble polysaccharide with a molar weight of 4.3 x 10(5) Da, termed as HBP was isolated from the fruit bodies of an edible mushroom, Sarcodon aspratus (Berk.) S. Ito. Composition, methylation analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy experiments were conducted to elucidate its structure. The results indicated that HBP is a glucan featuring a backbone of (1 -> 6)-linked-beta-D-glucopyranosyl residues, which occasionally branched at O-3 position on along the backbone and substituted by the side chains that consisting of (1 -> 3)-linked-beta-D-glucopyranosyl, (1 -> 4)-linked-beta-D-glucopyranosyl and non-reducing end beta-D-glucopyranosyl residues. Immunological activity evaluation by H-3-thymidine incorporation method revealed that HBP can significantly stimulate the proliferation of the cultured mice spleen lymphocyte in a dose-dependent manner, thus, HBP is a promising potential immunomodulator that can be used as healthcare food or medicine against pathogens and tumors. (C) 2010 Elsevier B.V. All rights reserved.
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