Anti-inflammatory effect of the polysaccharides of Golden needle mushroom in burned rats

The present study was to investigate chemical components of polysaccharides isolated from Golden needle (GNP) mushroom using high performance liquid chromatography (HPLC) and nuclear magnetic resonance spectroscopy (NMR). Then, anti-inflammatory effect of the polysaccharides was also evaluated. Results indicated that GNP was composed of the three monosaccharides (glucose, mannose and xylose) with a molar ratio of 3.5:0.8:1.4. GNP could significantly decreased CD4(+) CD8(+), ICAM-1, and MPO in serum and colon of normal and burned rats. It could be concluded that GNP possessed strong anti-inflammatory activity in burned rats. (C) 2009 Elsevier B.V. All rights reserved.