Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 44, Issue 2, Pages 170-174Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2008.11.010
Keywords
Fucoidan; Phosphorylated; Aminated; Antioxidant activity
Funding
- Key Project of Scientific and Technical of Shandong [2007 GG10005007]
- Innovative Key Project of the Chinese Academy of Sciences [KZCX2-YW-209]
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Three sulfated polysaccharide derivatives (phosphorylated and aminated fucoidan) were synthesized, and their potential antioxidant activities were investigated employing various established in vitro systems. Two methods were used in phosphorylation fucoidan: polyphosphoric acid and POCl3 method. Aminated fucoidan was prepared using the epichlorohydrin and ammonia water. All fucoidan derivatives possessed considerable antioxidant activity, and exhibited stronger antioxidant ability than fucoidan in certain tests. The phosphorylated fucoidan showed stronger hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and reducing power. The mechanism on influence the antioxidant activity of samples of phosphate and amino group was indicated. (C) 2008 Elsevier B.V. All rights reserved.
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