Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 44, Issue 1, Pages 70-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2008.10.003
Keywords
Sulfated polysaccharide; Chemical characteristic; Anticoagulant activity
Funding
- Science and Technology Development Program of Shandong Province (China) [2006GG2205014]
- Nature Science Foundation of Shandong Province (China) [Y2007D03]
- Science and Technology Development Program of Qingdao (China) [06-2-2-4-nsh]
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A polysaccharide was isolated from marine green algae Monostroma latissimum, and its chemical characteristic and anticoagulant activity were investigated. The results demonstrated that the polysaccharide was high rhamnose-containing sulfated polysaccharide, and was mainly composed of 1,2-linked L-rhamnose residues with sulfate groups substituted at positions C-3 and/or C-4. The sulfated polysaccharide exhibited high anticoagulant activities by assays of the activated partial thromboplastin time (APTT) and thrombin time (TT). The anticoagulant property of the sulfated polysaccharide was mainly attributed to powerful potentiation thrombin by heparin cofactor II. (C) 2008 Elsevier B.V. All rights reserved.
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