Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 44, Issue 5, Pages 435-440Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2009.03.004
Keywords
Cation-independent mannose 6-phosphate receptor; Reptiles (calotes); IGF-II binding; M6P/IGF-II receptor; Evolution
Funding
- DST [SR/SO/BB/60-2003]
- Volkswagen Stiftung, Germany [1/78913]
- CSIR, New Delhi, India
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The mammalian cation-independent mannose 6-phosphate/insulin-like growth factor (IGF)-II receptor binds IGF-II with high affinity. Ligands transported by the MPR 300/IGF-IIR include IGF-II and mannose 6-phosphate-modified proteins. By targeting IGF-II to lysosomal degradation, it plays a key role in the maintenance of correct IGF-II levels in the circulation and in target tissues. Although, from our studies we found homologous receptor in calotes but its functional significance was not known. We present here the first report on the calotes MPR 300/IGF-IIR binds IGF-II with K-d of 12.02 nM; these findings provide new and strong evidence that MPR 300/IGF-IIR in Calotes versicolor binds IGFII with high affinity. (C) 2009 Elsevier B.V. All rights reserved.
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