Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 42, Issue 4, Pages 324-334Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2007.12.004
Keywords
electrospinning; nanofibrous scaffolds; human epidermal keratinocytes
Funding
- National Research Foundation of Korea [R11-2000-084-11003-0, 핵06B1310, R11-2000-084-07004-0, R11-2000-084-10001-0, 전06A1202] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds. (c) 2008 Elsevier B.V. All rights reserved.
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