Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 43, Issue 3, Pages 320-324Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2008.06.006
Keywords
solid lipid nanoparticles; liver targeting; taspine
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Taspine solid lipid nanoparticles (Ta-SLN) and taspine solid lipid nanoparticles modified by galactoside (Ta-G(2)SLN) were prepared by the film evaporation-extrusion method. The nanoparticles were spherical or near-spherical particles with smooth surface, small size and high encapsulation efficiency. Ta-G(2)SLN and Ta-SLN showed significant inhibition on 7721 cell growth. Intravenous injection of either Ta-SLN or Ta-G(2)SLN resulted in a higher plasma and liver concentration and a longer retention time in mice compared with the administration of Ta. These results suggested that SLN tended to be preferentially delivered to the liver and Ta-G(2)SLN may further enhance liver targeting. (C) 2008 Elsevier B.V. All rights reserved.
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