Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 42, Issue 4, Pages 314-323Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2007.11.002
Keywords
aspirin; fatty acid; albumin; binding; quenching fluorescence method
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Saturated fatty acids such as myristic acid play an important role in the pathogenesis of cardiovascular disorders. Using the quenching fluorescence method we examined the influence of myristate on the changes of transporting protein affinity towards aspirin-the most popular anticoagulant. Our results showed that the presence of the myristic acid alters the stability of the anticoagulant-albumin complex. The ranges of [myristate]/[albumin] molar ratio at which the stability of drug-protein complex increases or decreases were determined. The differences in interaction between ligands and human or bovine serum albumins were identified. The competition in binding of ligands with these albumins was also described. (c) 2008 Published by Elsevier B.V.
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