Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 51, Issue -, Pages 89-92Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.03.029
Keywords
beta-Thalassemia; Polycythemia vera; Chronic stress erythropoiesis; Iron metabolism; Macrophages
Categories
Funding
- NIDDK NIH HHS [R01 DK090554, R01 DK095112, R21 DK065169] Funding Source: Medline
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beta-Thalassemia and Polycythemia vera are genetic disorders which affect the synthesis of red blood cells, also referred to as erythropoiesis. Although essentially different in clinical presentation - patients with beta-thalassemia have an impairment in beta-globin synthesis leading to defective erythrocytes and anemia, while patients with Polycythemia vera present with high hemoglobin levels because of excessive red blood cell synthesis - both pathologies may characterized by lasting high erythropoietic activity, i.e. chronic stress erythropoiesis. In both diseases, therapeutic strategies targeting chronic stress erythropoiesis may improve the address phenotype and prevent secondary pathology, such as iron overload. The current review will address the basic concepts of these strategies to reduce chronic stress erythropoiesis, which may have significant clinical implications in the near future. (C) 2014 Elsevier Ltd. All rights reserved.
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