Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 54, Issue -, Pages 312-317Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.05.040
Keywords
microRNA-7; Tumor suppressor; Cancer; Epidermal growth factor receptor
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Funding
- National Health and Medical Research Council (NHMRC) of Australia [634375, 458649]
- Cancer Council of Western Australia (CCWA)
- Medical Research Commercialisation Fund (MRCF)
- Scott Kirkbride Melanoma Research Centre (SKMRC)
- Royal Perth Hospital Medical Research Foundation
- Harry Perkins Institute of Medical Research
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microRNAs are a family of endogenous, short, non-coding RNAs that play critical roles in regulating gene expression for key cellular processes in normal and abnormal physiology. microRNA-7 is a 23 nucleotide miRNA whose expression is tightly regulated and restricted predominantly to the brain, spleen and pancreas. Reduced levels of miR-7 have been linked to the development of cancer and metastasis. As a tumor suppressor, miR-7 functions to co-ordinately downregulate a number of direct (e.g. the epidermal growth factor receptor) and indirect (e.g. phospho-Akt) growth promoting targets to decrease tumor growth in vitro and in vivo. In addition, miR-7 can increase the sensitivity of treatment-resistant cancer cells to therapeutics and inhibit metastasis. These data suggest that replacement of miR-7 ('miRNA replacement therapy') for specific human cancers could represent a new treatment approach. (C) 2014 Elsevier Ltd. All rights reserved.
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