Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 45, Issue 8, Pages 1585-1593Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2013.04.029
Keywords
MiR-224; Fatty acid metabolism; Adipogenesis; EGR2; ACSL4
Categories
Funding
- National Natural Science Foundation of China [31272425]
- National Science & Technology Pillar Program during the Twelfth Five-year Plan Period [2011BAD28B01]
- Science and Technology Planning Project of Hubei Province, China [2011BBB090]
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MicroRNAs (miRNAs) are small similar to 22 nucleotide regulatory RNAs that regulate the stability and translation of cognate messenger RNAs (mRNAs). MicroRNAs participate in the regulation of adipogenesis and identification of the full repertoire of MicroRNAs expressed in adipose tissue is likely to improve our understanding of adipose tissue growth and development significantly. In the present study, it is found that miR-224-5p abundance decreases first and then increases during adipogenesis of 3T3-L1 cells. And early growth response 2 (EGR2) and Acyl-CoA synthetase long-chain family member 4 (ACSL4) are direct targets of miR-224-5p. Further studies in mouse 3T3-L1 cell-line shows that miR-224-5p is a novel negative regulator of adipocyte differentiation through post-transcriptional regulation of early growth response 2 during early adipogenesis. Furthermore, miR-224-5p could regulate fatty acid metabolism through Acyl-CoA synthetase long-chain family member 4 at terminal differentiation. It indicates that miR-224 plays different roles on different stages of adipogenesis. Crown Copyright (c) 2013 Published by Elsevier Ltd. All rights reserved.
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